This lesson plan, from the University of Wisconsin-Madisons Wisconsin Fast Plants, is for a high school biology investigation into evolution and artificial selection while using Fast Plants polycot seeds. The lesson plan describes student science performance for in-classroom learning as well as distance learning, and assessment for student learning. Additionally, this resource includes a sample calendar to demonstrate how educators can implement this investigation into their classroom. This resource is related to Evidence of Natural Selection Activities and Investigating Selection with New Polycots Fast Plants, which are available to view separately.